| 1 |
Mapoly0051s0085
| [KOG2267] Eukaryotic-type DNA primase, large subunit; [GO:0006269] DNA replication, synthesis of RNA primer; [GO:0003896] DNA primase activity; [PTHR10537] DNA PRIMASE LARGE SUBUNIT; [K02685] DNA primase large subunit [EC:2.7.7.-]; [PF04104] Eukaryotic and archaeal DNA primase, large subunit; [2.7.7.-] Nucleotidyltransferases. | 2.83 | 0.8561 |
| 2 |
Mapoly0060s0105
| [PTHR24012] FAMILY NOT NAMED; [KOG4207] Predicted splicing factor, SR protein superfamily; [GO:0008270] zinc ion binding; [PF00098] Zinc knuckle; [GO:0003676] nucleic acid binding; [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 2.83 | 0.8551 |
| 3 |
Mapoly0043s0128
| [KOG0381] HMG box-containing protein; [GO:0003677] DNA binding; [PF00505] HMG (high mobility group) box; [PF01388] ARID/BRIGHT DNA binding domain; [PTHR13711] SWI/SNF-RELATED CHROMATIN BINDING PROTEIN; [GO:0005622] intracellular | 3.46 | 0.8361 |
| 4 |
Mapoly0185s0017
| [GO:0030915] Smc5-Smc6 complex; [PF08746] RING-like domain; [KOG4718] Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1); [PTHR20973] NON-SMC ELEMENT 1-RELATED; [PF07574] Nse1 non-SMC component of SMC5-6 complex; [GO:0006281] DNA repair; [PTHR20973:SF0] SUBFAMILY NOT NAMED | 5.00 | 0.8426 |
| 5 |
Mapoly0029s0012
| [GO:0005524] ATP binding; [PF00270] DEAD/DEAH box helicase; [PF00271] Helicase conserved C-terminal domain; [KOG0329] ATP-dependent RNA helicase; [PTHR24031] FAMILY NOT NAMED; [GO:0003676] nucleic acid binding | 5.48 | 0.8502 |
| 6 |
Mapoly0155s0001
| [GO:0016597] amino acid binding; [PF01842] ACT domain; [GO:0008152] metabolic process; [PTHR31096] FAMILY NOT NAMED | 6.00 | 0.8229 |
| 7 |
Mapoly0063s0059
| [GO:0000812] Swr1 complex; [GO:0006338] chromatin remodeling; [GO:0006355] regulation of transcription, DNA-dependent; [GO:0031011] Ino80 complex; [PTHR11937:SF47] SUBFAMILY NOT NAMED; [GO:0035267] NuA4 histone acetyltransferase complex; [PF00022] Actin; [GO:0006281] DNA repair; [PTHR11937] ACTIN; [KOG0679] Actin-related protein - Arp4p/Act3p | 6.48 | 0.8300 |
| 8 |
Mapoly0015s0045
| [KOG0533] RRM motif-containing protein; [PTHR19965] RNA AND EXPORT FACTOR BINDING PROTEIN; [K12881] THO complex subunit 4; [PF13865] C-terminal duplication domain of Friend of PRMT1; [GO:0003676] nucleic acid binding; [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 7.75 | 0.8179 |
| 9 |
Mapoly0101s0048
| [K10752] histone-binding protein RBBP4; [GO:0005515] protein binding; [KOG0264] Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1; [PTHR22850] WD40 REPEAT FAMILY; [PF12265] Histone-binding protein RBBP4 or subunit C of CAF1 complex; [PF00400] WD domain, G-beta repeat | 8.49 | 0.8481 |
| 10 |
Mapoly0080s0039
| [PTHR15081] NUCLEAR AUTOANTIGENIC SPERM PROTEIN (NASP)-RELATED; [PF13414] TPR repeat; [PF10516] SHNi-TPR | 11.00 | 0.8191 |
| 11 |
Mapoly0012s0102
| [PTHR23365] POLY-A BINDING PROTEIN 2; [K14396] polyadenylate-binding protein 2; [KOG4209] Splicing factor RNPS1, SR protein superfamily; [GO:0003676] nucleic acid binding; [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 12.69 | 0.8079 |
| 12 |
Mapoly0007s0066
| [GO:0030915] Smc5-Smc6 complex; [PTHR19306] STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 (SMC5, SMC6); [PTHR19306:SF1] STRUCTURAL MAINTENANCE OF CHROMOSOMES 5 SMC5; [KOG0979] Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily; [PF02463] RecF/RecN/SMC N terminal domain; [GO:0006281] DNA repair; [GO:0000724] double-strand break repair via homologous recombination | 13.04 | 0.8192 |
| 13 |
Mapoly0084s0054
| [K03029] 26S proteasome regulatory subunit N10; [PF02809] Ubiquitin interaction motif; [PF13519] von Willebrand factor type A domain; [GO:0006511] ubiquitin-dependent protein catabolic process; [PTHR10223] 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4; [GO:0008540] proteasome regulatory particle, base subcomplex; [KOG2884] 26S proteasome regulatory complex, subunit RPN10/PSMD4 | 13.42 | 0.8127 |
| 14 |
Mapoly0011s0143
| [PTHR15481:SF0] SUBFAMILY NOT NAMED; [K14325] RNA-binding protein with serine-rich domain 1; [PTHR15481] RIBONUCLEIC ACID BINDING PROTEIN S1; [GO:0003676] nucleic acid binding; [KOG0130] RNA-binding protein RBM8/Tsunagi (RRM superfamily); [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 13.56 | 0.8263 |
| 15 |
Mapoly0053s0080
| [GO:0006396] RNA processing; [GO:0003723] RNA binding; [PF12230] Pre-mRNA splicing factor PRP21 like protein; [GO:0005515] protein binding; [PTHR15316:SF1] SPLICEOSOME ASSOCIATED PROTEIN 114; [PF00240] Ubiquitin family; [K12825] splicing factor 3A subunit 1; [PTHR15316] SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED; [PF01805] Surp module; [KOG0007] Splicing factor 3a, subunit 1 | 14.07 | 0.8135 |
| 16 |
Mapoly0024s0018
| [PTHR23147] SERINE/ARGININE RICH SPLICING FACTOR; [KOG4207] Predicted splicing factor, SR protein superfamily; [K12891] splicing factor, arginine/serine-rich 2; [GO:0003676] nucleic acid binding; [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 16.25 | 0.8065 |
| 17 |
Mapoly0107s0034
| [3.5.1.98] Histone deacetylase.; [KOG1342] Histone deacetylase complex, catalytic component RPD3; [K06067] histone deacetylase 1/2 [EC:3.5.1.98]; [PF00850] Histone deacetylase domain; [PTHR10625] HISTONE DEACETYLASE | 17.23 | 0.7986 |
| 18 |
Mapoly0005s0061
| [PF00089] Trypsin; [PTHR22939] SERINE PROTEASE FAMILY S1C HTRA-RELATED; [GO:0005515] protein binding; [PF13180] PDZ domain; [KOG1320] Serine protease; [GO:0004252] serine-type endopeptidase activity; [GO:0006508] proteolysis | 17.75 | 0.7982 |
| 19 |
Mapoly0023s0117
| [PTHR10139] DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11A; [PF04152] Mre11 DNA-binding presumed domain; [KOG2310] DNA repair exonuclease MRE11; [GO:0006259] DNA metabolic process; [PF00149] Calcineurin-like phosphoesterase; [GO:0006302] double-strand break repair; [GO:0016787] hydrolase activity; [GO:0030145] manganese ion binding; [GO:0005634] nucleus; [GO:0004527] exonuclease activity; [K10865] double-strand break repair protein MRE11; [GO:0004519] endonuclease activity | 18.97 | 0.8003 |
| 20 |
Mapoly0095s0052
| [PF08839] DNA replication factor CDT1 like | 19.08 | 0.8150 |
| 21 |
Mapoly0079s0005
| [GO:0008080] N-acetyltransferase activity; [GO:0016568] chromatin modification; [PF00583] Acetyltransferase (GNAT) family; [GO:0005634] nucleus; [GO:0004402] histone acetyltransferase activity; [GO:0016573] histone acetylation; [KOG2696] Histone acetyltransferase type b catalytic subunit; [GO:0006348] chromatin silencing at telomere; [2.3.1.48] Histone acetyltransferase.; [PTHR12046] HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT; [K11303] histone acetyltransferase 1 [EC:2.3.1.48]; [PF10394] Histone acetyl transferase HAT1 N-terminus | 20.86 | 0.8148 |
| 22 |
Mapoly0074s0043
| [GO:0005685] U1 snRNP; [GO:0006376] mRNA splice site selection; [PF03194] LUC7 N_terminus; [PTHR12375] RNA-BINDING PROTEIN LUC7-RELATED; [GO:0003729] mRNA binding | 20.90 | 0.8129 |
| 23 |
Mapoly0014s0096
| [GO:0005524] ATP binding; [K10755] replication factor C subunit 2/4; [KOG0989] Replication factor C, subunit RFC4; [PTHR11669] REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; [PF00004] ATPase family associated with various cellular activities (AAA); [PF08542] Replication factor C C-terminal domain | 21.49 | 0.7936 |
| 24 |
Mapoly0001s0348
| [KOG1342] Histone deacetylase complex, catalytic component RPD3; [PF00850] Histone deacetylase domain; [PTHR10625] HISTONE DEACETYLASE | 22.14 | 0.7714 |
| 25 |
Mapoly0005s0155
| [PF03517] Regulator of volume decrease after cellular swelling; [GO:0006821] chloride transport; [GO:0005829] cytosol; [GO:0005886] plasma membrane; [GO:0006884] cell volume homeostasis; [K05019] chloride channel, nucleotide-sensitive, 1A; [GO:0034709] methylosome; [GO:0034715] pICln-Sm protein complex; [KOG3238] Chloride ion current inducer protein; [PTHR21399] CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN; [GO:0000387] spliceosomal snRNP assembly | 23.09 | 0.7937 |
| 26 |
Mapoly0086s0078
| [GO:0003677] DNA binding; [GO:0006275] regulation of DNA replication; [GO:0030337] DNA polymerase processivity factor activity; [PTHR11352] PROLIFERATING CELL NUCLEAR ANTIGEN; [PF00705] Proliferating cell nuclear antigen, N-terminal domain; [KOG1636] DNA polymerase delta processivity factor (proliferating cell nuclear antigen); [PF02747] Proliferating cell nuclear antigen, C-terminal domain | 23.37 | 0.8039 |
| 27 |
Mapoly0051s0073
| [PF14675] FANCI solenoid 1; [PTHR21818:SF0] SUBFAMILY NOT NAMED; [PF14680] FANCI helical domain 2; [KOG4553] Uncharacterized conserved protein; [K10895] fanconi anemia group I protein; [PF14679] FANCI helical domain 1; [GO:0006281] DNA repair; [PF14678] FANCI solenoid 4; [PTHR21818] BC025462 PROTEIN; [PF14676] FANCI solenoid 2 | 23.64 | 0.8170 |
| 28 |
Mapoly0036s0154
| [KOG2606] OTU (ovarian tumor)-like cysteine protease; [PTHR12419] OTU DOMAIN CONTAINING PROTEIN; [PTHR12419:SF10] gb def: ENSANGP00000019868 (Fragment); [PF02338] OTU-like cysteine protease | 25.51 | 0.8125 |
| 29 |
Mapoly0151s0042
| [PTHR31500:SF0] SUBFAMILY NOT NAMED; [PF03479] Domain of unknown function (DUF296); [PTHR31500] FAMILY NOT NAMED | 27.24 | 0.7863 |
| 30 |
Mapoly0091s0013
| [GO:0003723] RNA binding; [KOG2202] U2 snRNP splicing factor, small subunit, and related proteins; [PF00642] Zinc finger C-x8-C-x5-C-x3-H type (and similar); [PTHR12620] U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT; [GO:0005634] nucleus; [K12836] splicing factor U2AF 35 kDa subunit; [PF13893] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); [GO:0046872] metal ion binding | 27.66 | 0.8141 |
| 31 |
Mapoly0040s0126
| [K03131] transcription initiation factor TFIID subunit 6; [GO:0006352] DNA-dependent transcription, initiation; [PF07571] Protein of unknown function (DUF1546); [PF02969] TATA box binding protein associated factor (TAF); [GO:0005634] nucleus; [GO:0051090] regulation of sequence-specific DNA binding transcription factor activity; [KOG2549] Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA); [PTHR10221] TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6 | 29.70 | 0.6655 |
| 32 |
Mapoly0152s0004
| [PTHR12460] CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN; [PTHR12460:SF4] SUBFAMILY NOT NAMED; [PF04818] RNA polymerase II-binding domain.; [KOG2669] Regulator of nuclear mRNA | 31.22 | 0.7945 |
| 33 |
Mapoly0014s0097
| [PF13414] TPR repeat; [KOG1308] Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein; [PTHR22904:SF34] HSC70-INTERACTING PROTEIN; [PTHR22904] TPR REPEAT CONTAINING PROTEIN | 32.00 | 0.7988 |
| 34 |
Mapoly0089s0012
| [GO:0003677] DNA binding; [KOG1745] Histones H3 and H4; [GO:0000786] nucleosome; [PTHR11426] HISTONE H3; [PF00125] Core histone H2A/H2B/H3/H4 | 32.03 | 0.7839 |
| 35 |
Mapoly0001s0378
| [PTHR32086] FAMILY NOT NAMED; [K10891] fanconi anemia group D2 protein; [GO:0006281] DNA repair; [KOG4712] Uncharacterized conserved protein; [PF14631] Fanconi anaemia protein FancD2 nuclease | 32.47 | 0.7983 |
| 36 |
Mapoly0014s0064
| [PTHR10552] U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A; [K11092] U2 small nuclear ribonucleoprotein A'; [KOG1644] U2-associated snRNP A' protein; [PF14580] Leucine-rich repeat | 32.86 | 0.7969 |
| 37 |
Mapoly0116s0028
| [PTHR23074:SF19] KATANIN-RELATED; [GO:0005524] ATP binding; [3.6.4.3] Microtubule-severing ATPase.; [K07767] microtubule-severing ATPase [EC:3.6.4.3]; [PF00004] ATPase family associated with various cellular activities (AAA); [KOG0738] AAA+-type ATPase; [PTHR23074] AAA ATPASE; [PF09336] Vps4 C terminal oligomerisation domain | 32.98 | 0.7766 |
| 38 |
Mapoly0052s0092
| [GO:0008270] zinc ion binding; [PF00098] Zinc knuckle; [GO:0003676] nucleic acid binding; [KOG0106] Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily); [PTHR10548] SPLICING FACTOR, ARGININE/SERINE-RICH; [PF00076] RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) | 33.17 | 0.7855 |
| 39 |
Mapoly0070s0095
| [PTHR23215] ZINC FINGER PROTEIN 207; [KOG2893] Zn finger protein | 33.47 | 0.7942 |
| 40 |
Mapoly0038s0027
| [GO:0008168] methyltransferase activity; [PTHR10629] CYTOSINE-SPECIFIC METHYLTRANSFERASE; [PF01426] BAH domain; [GO:0003682] chromatin binding; [K00558] DNA (cytosine-5-)-methyltransferase [EC:2.1.1.37]; [PTHR10629:SF11] CYTOSINE-SPECIFIC METHYLTRANSFERASE; [PF12047] Cytosine specific DNA methyltransferase replication foci domain; [PF00145] C-5 cytosine-specific DNA methylase; [2.1.1.37] DNA (cytosine-5-)-methyltransferase. | 33.91 | 0.7904 |
| 41 |
Mapoly0028s0066
| [GO:0005524] ATP binding; [KOG1112] Ribonucleotide reductase, alpha subunit; [GO:0006260] DNA replication; [GO:0055114] oxidation-reduction process; [GO:0004748] ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; [PF00317] Ribonucleotide reductase, all-alpha domain; [PTHR11573] RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; [PTHR11573:SF6] RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; [PF02867] Ribonucleotide reductase, barrel domain; [1.17.4.1] Ribonucleoside-diphosphate reductase.; [K10807] ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]; [PF03477] ATP cone domain | 34.47 | 0.8025 |
| 42 |
Mapoly0030s0009
| [PF00505] HMG (high mobility group) box; [KOG0526] Nucleosome-binding factor SPN, POB3 subunit; [PF03531] Structure-specific recognition protein (SSRP1); [PTHR13711:SF39] SUBFAMILY NOT NAMED; [PTHR13711] SWI/SNF-RELATED CHROMATIN BINDING PROTEIN; [PF08512] Histone chaperone Rttp106-like; [K09272] structure-specific recognition protein 1 | 34.70 | 0.7932 |
| 43 |
Mapoly0015s0164
| [GO:0003677] DNA binding; [PF02362] B3 DNA binding domain; [PTHR31391] FAMILY NOT NAMED | 34.96 | 0.7893 |
| 44 |
Mapoly0075s0022
| [KOG0482] DNA replication licensing factor, MCM7 component; [GO:0003677] DNA binding; [GO:0005524] ATP binding; [GO:0006260] DNA replication; [K02210] minichromosome maintenance protein 7 (cell division control protein 47); [PF00493] MCM2/3/5 family; [GO:0042555] MCM complex; [GO:0005634] nucleus; [GO:0006270] DNA replication initiation; [PTHR11630] DNA REPLICATION LICENSING FACTOR; [GO:0003678] DNA helicase activity; [PF14551] MCM N-terminal domain; [PTHR11630:SF26] DNA REPLICATION LICENSING FACTOR MCM7 | 35.33 | 0.8145 |
| 45 |
Mapoly0024s0061
| [KOG1508] DNA replication factor/protein phosphatase inhibitor SET/SPR-2; [PF00956] Nucleosome assembly protein (NAP); [GO:0005634] nucleus; [GO:0006334] nucleosome assembly; [K11290] template-activating factor I; [PTHR11875] TESTIS-SPECIFIC Y-ENCODED PROTEIN | 36.93 | 0.7995 |
| 46 |
Mapoly0010s0010
| [GO:0005643] nuclear pore; [PF13874] Nucleoporin complex subunit 54; [PTHR13000] NUCLEOPORIN P54; [KOG3091] Nuclear pore complex, p54 component (sc Nup57) | 37.04 | 0.7884 |
| 47 |
Mapoly0061s0010
| [GO:0006269] DNA replication, synthesis of RNA primer; [GO:0003896] DNA primase activity; [PTHR10536] DNA PRIMASE SMALL SUBUNIT; [KOG2851] Eukaryotic-type DNA primase, catalytic (small) subunit; [K02684] DNA primase small subunit [EC:2.7.7.-]; [2.7.7.-] Nucleotidyltransferases.; [PF01896] Eukaryotic and archaeal DNA primase small subunit | 37.82 | 0.8108 |
| 48 |
Mapoly0002s0237
| [PTHR12864] RAN BINDING PROTEIN 9-RELATED; [PF10607] CTLH/CRA C-terminal to LisH motif domain; [GO:0005515] protein binding; [KOG1477] SPRY domain-containing proteins; [PTHR12864:SF1] RAN BINDING PROTEIN 9-RELATED; [PF00622] SPRY domain | 38.57 | 0.7066 |
| 49 |
Mapoly0013s0062
| [GO:0003677] DNA binding; [PTHR15348:SF0] SUBFAMILY NOT NAMED; [PF01388] ARID/BRIGHT DNA binding domain; [GO:0005622] intracellular; [PTHR15348] AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN (ARID DOMAIN- CONTAINING PROTEIN) (DEAD RINGER PROTEIN) (B-CELL REGULATOR OF IGH TRANSCRIPTION) (BRIGHT) | 40.80 | 0.7957 |
| 50 |
Mapoly0105s0060
| [PF14259] RNA recognition motif (a.k.a. RRM, RBD, or RNP domain); [K12898] heterogeneous nuclear ribonucleoprotein F/H; [KOG4211] Splicing factor hnRNP-F and related RNA-binding proteins; [PTHR13976] HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED | 40.99 | 0.8009 |
